Delivering the Utmost in Multiplex Functionality and Sensitivity
Cambridge Biomedical has optimized and validated multiple biomarker assays using the Meso Scale Discovery® (MSD) platform. The MSD technology facilitates the detection of biomarkers such as cytokines and intracellular signaling proteins within complex sample matrices.
MSD’s core technology combines the use of electrochemiluminescence and MULTI-ARRAY® technology to provide both multiplex functionality and sensitivity. MSD’s electrochemiluminescence detection technology utilizes SULFO-TAG™ conjugated labels that emit light upon electrochemical stimulation, initiated at the electrode surfaces of MULTI-ARRAY and MULTI-SPOT® microplates.
Electrochemiluminescence offers significant advantages over traditional ELISA assays including low background, signal amplification, improved sensitivity, and dynamic range. In a multiplex array, the MSD platform facilitates the detection of up to 10 analytes from a single sample. The MSD catalog includes a large selection of single and multiplex kits for profiling biomarkers, cell signaling pathways as well as other applications.
Cambridge Biomedical and Btk
Cambridge Biomedical scientists have significant experience in MSD assay transfer, development, and optimization as well as sample testing in support of clinical trials at multiple stages. Among the clinical studies that Cambridge Biomedical has, many contributions include receptor occupancy assays such as free uninhibited Btk target site occupancy in human B cell lysates.