Analyzing the Immunological Response to Your Therapeutic
Immunogenicity studies aim to detect the presence of immune response against a therapeutic drug. This can be a humoral (anti-drug antibody) or cellular (T-cell) response. This response can arise when the organism, human or animal, recognizes the drug as foreign. Though not necessarily a toxicological endpoint, immunogenicity can affect the pharmacokinetic and/or the pharmacodynamics profile of a drug.
Services and Capabilities
Cambridge Biomedical has developed and validated many different immunogenicity assays for clinical trials and preclinical studies. We have experience with a variety of large and small molecule drugs and in both human and animal samples.
We can recommend strategies and provide contract services for assessing immunogenicity using a variety of technologies.
Cell-based neutralizing assays
Our Immunology Testing Services:
NK cell killing (cytotoxicity)
Phagocytosis or Phagoburst™ (neutrophils and monocytes)
Individual and multiplex cytokine analysis
Cytokine release syndrome (cytokine storm)