Analytical Options for Immuno-Oncology Studies


The biomarker options for immuno-oncology clinical trials are vast and a targeted approach is beneficial. A broad range of analytical methods across diverse matrices, including tumor, blood, cells, and DNA/RNA, is necessary to paint the best, most colorful and informative picture. 

Options include:

  • The measurement of circulating proteins in the blood using immunoassays

  • The examination of the cellular component of the blood, including the analysis of circulating tumor cells and/or circulating free DNA via flow cytometry

  • Tumor gene expression by PCR


Patient samples are precious and are often subject to limited availability — either in terms of the biopsy material available or blood volume restriction. This necessitates highly sensitive and reproducible assays capable of running small sample volumes, such as the multiplex assays described above. Immunoassays and flow cytometry allow more data to be generated from the smallest amount of sample.



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